Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern
Identifieur interne : 000160 ( Main/Exploration ); précédent : 000159; suivant : 000161Evolutionary Plasticity of Habenular Asymmetry with a Conserved Efferent Connectivity Pattern
Auteurs : Aldo Villal N [Chili] ; Mauricio Sepúlveda [Chili] ; Néstor Guerrero [Chili] ; Margarita M. Meynard [Chili] ; Karina Palma [Chili] ; Miguel L. Concha [Chili]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain. One key feature of this bilateral nucleus is the presence of left-right differences in size, cytoarchitecture, connectivity, neurochemistry and/or gene expression. In teleosts, habenular asymmetry has been associated with preferential innervation of left-right habenular efferents into dorso-ventral domains of the midbrain interpeduncular nucleus (IPN). However, the degree of conservation of this trait and its relation to the structural asymmetries of the Hb are currently unknown. To address these questions, we performed the first systematic comparative analysis of structural and connectional asymmetries of the Hb in teleosts. We found striking inter-species variability in the overall shape and cytoarchitecture of the Hb, and in the frequency, strength and to a lesser degree, laterality of habenular volume at the population level. Directional asymmetry of the Hb was either to the left in D. rerio, E. bicolor, O. latipes, P. reticulata, B. splendens, or to the right in F. gardneri females. In contrast, asymmetry was absent in P. scalare and F. gardneri males at the population level, although in these species the Hb displayed volumetric asymmetries at the individual level. Inter-species variability was more pronounced across orders than within a single order, and coexisted with an overall conserved laterotopic representation of left-right habenular efferents into dorso-ventral domains of the IPN. These results suggest that the circuit design involving the Hb of teleosts promotes structural flexibility depending on developmental, cognitive and/or behavioural pressures, without affecting the main midbrain connectivity output, thus unveiling a key conserved role of this connectivity trait in the function of the circuit. We propose that ontogenic plasticity in habenular morphogenesis underlies the observed inter-species variations in habenular asymmetric morphology.
Url:
DOI: 10.1371/journal.pone.0035329
PubMed: 22514727
PubMed Central: 3325962
Affiliations:
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wicri:level="1"><nlm:aff id="aff1"><addr-line>Biomedical Neuroscience Institute (BNI), Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Biomedical Neuroscience Institute (BNI), Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Faculty of Medicine, Universidad Diego Portales, Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Faculty of Medicine, 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Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Meynard, Margarita M" sort="Meynard, Margarita M" uniqKey="Meynard M" first="Margarita M." last="Meynard">Margarita M. Meynard</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Biomedical Neuroscience Institute (BNI), Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Biomedical Neuroscience Institute (BNI), Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Palma, Karina" sort="Palma, Karina" uniqKey="Palma K" first="Karina" last="Palma">Karina Palma</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Biomedical Neuroscience Institute (BNI), Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Biomedical Neuroscience Institute (BNI), Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Concha, Miguel L" sort="Concha, Miguel L" uniqKey="Concha M" first="Miguel L." last="Concha">Miguel L. Concha</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Biomedical Neuroscience Institute (BNI), Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Biomedical Neuroscience Institute (BNI), Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Anatomy and Developmental Biology Program, Faculty of Medicine, Institute of Biomedical Sciences, Universidad de Chile, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The vertebrate habenulae (Hb) is an evolutionary conserved dorsal diencephalic nuclear complex that relays information from limbic and striatal forebrain regions to the ventral midbrain. One key feature of this bilateral nucleus is the presence of left-right differences in size, cytoarchitecture, connectivity, neurochemistry and/or gene expression. In teleosts, habenular asymmetry has been associated with preferential innervation of left-right habenular efferents into dorso-ventral domains of the midbrain interpeduncular nucleus (IPN). However, the degree of conservation of this trait and its relation to the structural asymmetries of the Hb are currently unknown. To address these questions, we performed the first systematic comparative analysis of structural and connectional asymmetries of the Hb in teleosts. We found striking inter-species variability in the overall shape and cytoarchitecture of the Hb, and in the frequency, strength and to a lesser degree, laterality of habenular volume at the population level. Directional asymmetry of the Hb was either to the left in D. rerio, E. bicolor, O. latipes, P. reticulata, B. splendens, or to the right in F. gardneri females. In contrast, asymmetry was absent in P. scalare and F. gardneri males at the population level, although in these species the Hb displayed volumetric asymmetries at the individual level. Inter-species variability was more pronounced across orders than within a single order, and coexisted with an overall conserved laterotopic representation of left-right habenular efferents into dorso-ventral domains of the IPN. These results suggest that the circuit design involving the Hb of teleosts promotes structural flexibility depending on developmental, cognitive and/or behavioural pressures, without affecting the main midbrain connectivity output, thus unveiling a key conserved role of this connectivity trait in the function of the circuit. We propose that ontogenic plasticity in habenular morphogenesis underlies the observed inter-species variations in habenular asymmetric morphology.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bianco, Ih" uniqKey="Bianco I">IH Bianco</name></author><author><name sortKey="Wilson, Sw" uniqKey="Wilson S">SW Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hikosaka, O" uniqKey="Hikosaka O">O Hikosaka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Concha, Ml" uniqKey="Concha M">ML Concha</name></author><author><name sortKey="Wilson, Sw" uniqKey="Wilson S">SW Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nieuwenhuys, R" uniqKey="Nieuwenhuys R">R Nieuwenhuys</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guglielmotti, V" uniqKey="Guglielmotti V">V 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Grillner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agetsuma, M" uniqKey="Agetsuma M">M Agetsuma</name></author><author><name sortKey="Aizawa, H" uniqKey="Aizawa H">H Aizawa</name></author><author><name sortKey="Aoki, T" uniqKey="Aoki T">T Aoki</name></author><author><name sortKey="Nakayama, R" uniqKey="Nakayama R">R Nakayama</name></author><author><name sortKey="Takahoko, M" uniqKey="Takahoko M">M Takahoko</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, A" uniqKey="Lee A">A Lee</name></author><author><name sortKey="Mathuru, As" uniqKey="Mathuru A">AS Mathuru</name></author><author><name sortKey="Teh, C" uniqKey="Teh C">C Teh</name></author><author><name sortKey="Kibat, C" uniqKey="Kibat C">C Kibat</name></author><author><name sortKey="Korzh, V" uniqKey="Korzh V">V Korzh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Okamoto, H" uniqKey="Okamoto H">H Okamoto</name></author><author><name sortKey="Agetsuma, M" uniqKey="Agetsuma M">M Agetsuma</name></author><author><name sortKey="Aizawa, H" uniqKey="Aizawa H">H Aizawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wagner, Gp" uniqKey="Wagner G">GP Wagner</name></author><author><name sortKey="Pavlicev, M" uniqKey="Pavlicev M">M Pavlicev</name></author><author><name sortKey="Cheverud, Jm" uniqKey="Cheverud J">JM Cheverud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Winther, Rg" uniqKey="Winther R">RG Winther</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolker, Ja" uniqKey="Bolker J">JA Bolker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nissl, F" uniqKey="Nissl F">F Nissl</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Chili</li></country></list><tree><country name="Chili"><noRegion><name sortKey="Villal N, Aldo" sort="Villal N, Aldo" uniqKey="Villal N A" first="Aldo" last="Villal N">Aldo Villal N</name></noRegion><name sortKey="Concha, Miguel L" sort="Concha, Miguel L" uniqKey="Concha M" first="Miguel L." last="Concha">Miguel L. Concha</name><name sortKey="Concha, Miguel L" sort="Concha, Miguel L" uniqKey="Concha M" first="Miguel L." last="Concha">Miguel L. Concha</name><name sortKey="Guerrero, Nestor" sort="Guerrero, Nestor" uniqKey="Guerrero N" first="Néstor" last="Guerrero">Néstor Guerrero</name><name sortKey="Guerrero, Nestor" sort="Guerrero, Nestor" uniqKey="Guerrero N" first="Néstor" last="Guerrero">Néstor Guerrero</name><name sortKey="Meynard, Margarita M" sort="Meynard, Margarita M" uniqKey="Meynard M" first="Margarita M." last="Meynard">Margarita M. Meynard</name><name sortKey="Meynard, Margarita M" sort="Meynard, Margarita M" uniqKey="Meynard M" first="Margarita M." last="Meynard">Margarita M. Meynard</name><name sortKey="Palma, Karina" sort="Palma, Karina" uniqKey="Palma K" first="Karina" last="Palma">Karina Palma</name><name sortKey="Palma, Karina" sort="Palma, Karina" uniqKey="Palma K" first="Karina" last="Palma">Karina Palma</name><name sortKey="Sepulveda, Mauricio" sort="Sepulveda, Mauricio" uniqKey="Sepulveda M" first="Mauricio" last="Sepúlveda">Mauricio Sepúlveda</name><name sortKey="Sepulveda, Mauricio" sort="Sepulveda, Mauricio" uniqKey="Sepulveda M" first="Mauricio" last="Sepúlveda">Mauricio Sepúlveda</name><name sortKey="Villal N, Aldo" sort="Villal N, Aldo" uniqKey="Villal N A" first="Aldo" last="Villal N">Aldo Villal N</name><name sortKey="Villal N, Aldo" sort="Villal N, Aldo" uniqKey="Villal N A" first="Aldo" last="Villal N">Aldo Villal N</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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